HIV macrophage biology

  our lab studies the replication of HIV in primary human macrophages, including those of the lung and in myeloid progenitors. 

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  we have developed molecular and cellular tools to report HIV replication and the subcellular localization of viral proteins in living cells.

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  our research aims to prevent the production of HIV particles within infected cells despite viral protein translation - this would allow for immune clearance of infected cells. 

reporters of viral replication

  we have created several cellular tools to report viral replication in cultured cells and live animals.

  live fluorescent and enzymatic readouts enable us to study of every step of viral replication.

  we use qualitative phenotypes at the single cell and subcellular levels to explain quantitative measurements of proviral transcription and virus production.

novel mouse models

  we are testing new transgenic mouse models to study replication of viruses in vivo, compartmentalization of disease processes to specific organ compartments, and to learn how lineage tracing and reporter mice can illuminate pathologic processes while modeling human disease in mice.

funding we gratefully acknowledge

NIH R21 OD037879

NIH K01 OD031968

Cornell CVM Research Council

Cornell Rapid Response Seed Grant